CaM
CaM or Calmodulin is a calcium-binding messenger protein expressed in all eukaryotic cells. It is involved in regulating numerous cellular processes and is a primary receptor of calcium signals.
Structure[edit | edit source]
Calmodulin is a small, highly conserved protein that is 148 amino acids long. The protein has two approximately symmetrical globular domains, each of which can bind two calcium ions.
Function[edit | edit source]
Calmodulin mediates processes such as inflammation, metabolism, apoptosis, smooth muscle contraction, intracellular movement, short-term and long-term memory, nerve growth and the immune response. It does this by binding to and regulating a multitude of different protein targets.
Interactions[edit | edit source]
Calmodulin can interact with a variety of different proteins, including protein kinases, phosphatases, nitric oxide synthase, and ryanodine receptors. It can also bind to the plasma membrane, cytoskeleton, and chromatin.
Clinical significance[edit | edit source]
Alterations in calmodulin function can lead to diseases such as arrhythmia, heart failure, Alzheimer's disease, and cancer.
See also[edit | edit source]
References[edit | edit source]
CaM Resources | ||
---|---|---|
|
|
Translate to: East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
Urdu,
বাংলা,
తెలుగు,
தமிழ்,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
European
español,
Deutsch,
français,
русский,
português do Brasil,
Italian,
polski
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD