Cabiralizumab
A monoclonal antibody for the treatment of various diseases
Cabiralizumab is a monoclonal antibody that targets the colony-stimulating factor-1 receptor (CSF1R). It is being investigated for its potential use in the treatment of various diseases, including cancer and autoimmune disorders.
Mechanism of Action[edit | edit source]
Cabiralizumab works by binding to the CSF1R, a receptor found on the surface of certain immune cells, including macrophages and monocytes. By inhibiting this receptor, cabiralizumab can modulate the activity of these immune cells, potentially reducing inflammation and altering the tumor microenvironment in cancer.
Clinical Development[edit | edit source]
Cabiralizumab is currently in clinical trials for several indications. It has shown promise in the treatment of pancreatic cancer when used in combination with other therapies. Additionally, it is being studied for its effects on rheumatoid arthritis and other inflammatory diseases.
Pancreatic Cancer[edit | edit source]
In studies involving patients with advanced pancreatic cancer, cabiralizumab has been combined with nivolumab, an immune checkpoint inhibitor, to evaluate its efficacy in enhancing anti-tumor immune responses.
Rheumatoid Arthritis[edit | edit source]
Cabiralizumab has also been tested in patients with rheumatoid arthritis, where it aims to reduce joint inflammation by targeting the CSF1R pathway.
Safety and Side Effects[edit | edit source]
As with many investigational drugs, cabiralizumab has been associated with certain side effects. Common adverse effects include fatigue, nausea, and changes in blood cell counts. Ongoing studies continue to monitor its safety profile.
Also see[edit | edit source]
- Monoclonal antibody therapy
- Immune checkpoint inhibitors
- Cancer immunotherapy
- Rheumatoid arthritis treatment
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