Cancer vaccines

Vaccines or candidate vaccines designed to prevent or treat cancer.

How are they produced?

Cancer vaccines are produced using the patient's own whole tumor cells as the source of antigens, or using tumor-specific antigens, often recombinantly produced. These vaccines are "autologous", being prepared from samples taken from the patient, and are specific to that patient.

Types

A cancer vaccine is a vaccine that either treats existing cancer or prevents development of cancer.

1. Vaccines that treat existing cancer are known as therapeutic cancer vaccines.
2. Vaccines that precent cancer are known as preventive cancer vaccines.

Immunesurveillance

Some researchers claim that cancerous cells routinely arise and are destroyed by the immune system (immunosurveillance); and that tumors form when the immune system fails to destroy them.

Review article

• An expert discussion of the role of cancer vaccines

References

• Schiller JT, Lowy DR, Frazer IH, Finn OJ, Vilar E, Lyerly HK, Gnjatic S, Zaidi N, Ott PA, Balachandran VP, Dietrich PY, Migliorini D, Vonderheide RH, Domchek SM. Cancer vaccines. Cancer Cell. 2022 Jun 13;40(6):559-564. doi: 10.1016/j.ccell.2022.05.015. PMID: 35700704; PMCID: PMC9190070.

Cancer vaccines Resources
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