Cathelicidin

Cathelicidin is a family of proteins that are classified as antimicrobial peptides. The cathelicidin family of peptides are classified as innate immunity peptides. Cathelicidins are found in many different species of animals, including humans.

Function

Cathelicidins serve a critical role in mammalian innate immune system. They are capable of killing a broad range of bacteria, fungi, and viruses. In addition to their antimicrobial activity, cathelicidins have been shown to have a number of other biological functions, including the ability to promote wound healing, and to modulate the immune system.

Structure

Cathelicidins are characterized by a highly conserved region (the cathelin domain) and a highly variable cathelicidin peptide domain. The cathelicidin peptide domain is responsible for the antimicrobial activity, while the cathelin domain is necessary for peptide processing.

Clinical significance

Alterations in the production or function of cathelicidin peptides have been implicated in diseases such as rosacea, atopic dermatitis, and psoriasis. In addition, cathelicidin peptides are being explored as potential therapeutic agents in the treatment of infectious diseases, wound healing, and immune disorders.

See also

• Antimicrobial peptides
• Innate immune system
• Protein
• Rosacea
• Atopic dermatitis
• Psoriasis

References

Cathelicidin Resources
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