Cefamandole
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Cefamandole is a cephalosporin antibiotic used to treat a variety of bacterial infections. It is a second-generation cephalosporin, which means it has a broader spectrum of activity compared to first-generation cephalosporins.
Mechanism of Action[edit]
Cefamandole works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which leads to the interruption of cell wall synthesis and ultimately causes bacterial cell death.
Pharmacokinetics[edit]
Cefamandole is administered via intravenous or intramuscular injection. It is well-distributed throughout the body and achieves therapeutic concentrations in various tissues and fluids. The drug is primarily excreted by the kidneys, and its elimination half-life is approximately 1 hour.
Clinical Uses[edit]
Cefamandole is used to treat infections caused by susceptible strains of bacteria, including:
- Respiratory tract infections
- Urinary tract infections
- Skin and soft tissue infections
- Bone and joint infections
Side Effects[edit]
Common side effects of cefamandole include:
- Allergic reactions such as rash and anaphylaxis
- Gastrointestinal disturbances like nausea and diarrhea
- Hematological effects such as eosinophilia and thrombocytopenia
Resistance[edit]
Bacterial resistance to cefamandole can occur through various mechanisms, including the production of beta-lactamase enzymes that degrade the antibiotic, and alterations in PBPs that reduce drug binding.
Related pages[edit]
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Cefamandole
