Cefluprenam

Cefluprenam

Cefluprenam is a broad-spectrum antibiotic belonging to the cephalosporin class. It is used to treat a variety of bacterial infections by inhibiting the synthesis of the bacterial cell wall. Cefluprenam is particularly effective against Gram-positive and Gram-negative bacteria.

Mechanism of Action

Cefluprenam works by binding to penicillin-binding proteins (PBPs) located inside the bacterial cell wall. This binding inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis. The inhibition of cell wall synthesis results in bacterial cell lysis and death.

Pharmacokinetics

Cefluprenam is administered via intravenous or intramuscular injection. It is well-distributed throughout the body, including the cerebrospinal fluid when the meninges are inflamed. The drug is primarily excreted unchanged in the urine.

Clinical Uses

Cefluprenam is used to treat a variety of infections, including:

• Respiratory tract infections
• Urinary tract infections
• Skin and soft tissue infections
• Intra-abdominal infections
• Sepsis

Side Effects

Common side effects of Cefluprenam include:

• Nausea
• Vomiting
• Diarrhea
• Rash
• Allergic reactions

Serious side effects may include:

• Anaphylaxis
• Clostridium difficile-associated diarrhea
• Seizures (particularly in patients with renal impairment)

Contraindications

Cefluprenam is contraindicated in patients with a known hypersensitivity to cephalosporins or any component of the formulation. Caution is advised in patients with a history of penicillin allergy due to possible cross-reactivity.

Related Pages

• Antibiotic
• Cephalosporin
• Penicillin
• Gram-positive bacteria
• Gram-negative bacteria
• Bacterial cell wall