Cefoselis
A cephalosporin antibiotic
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Cefoselis is a cephalosporin antibiotic used in the treatment of various bacterial infections. It belongs to the fourth generation of cephalosporins and is known for its broad-spectrum activity against both Gram-positive and Gram-negative bacteria.
Mechanism of Action[edit | edit source]
Cefoselis works by inhibiting the synthesis of the bacterial cell wall. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which inhibits the final transpeptidation step of peptidoglycan synthesis. This action results in the weakening of the bacterial cell wall and ultimately leads to cell lysis and death.
Clinical Uses[edit | edit source]
Cefoselis is primarily used to treat severe infections caused by susceptible bacteria. These infections include:
Pharmacokinetics[edit | edit source]
Cefoselis is administered intravenously. It has a high affinity for binding to plasma proteins and is primarily excreted unchanged in the urine. The elimination half-life of cefoselis is approximately 1.5 to 2 hours.
Side Effects[edit | edit source]
Common side effects of cefoselis include:
Related Pages[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
