Cefoselis

Cefoselis

Cefoselis is a cephalosporin antibiotic used in the treatment of various bacterial infections. It belongs to the fourth generation of cephalosporins and is known for its broad-spectrum activity against both Gram-positive and Gram-negative bacteria.

Mechanism of Action

Cefoselis works by inhibiting the synthesis of the bacterial cell wall. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which inhibits the final transpeptidation step of peptidoglycan synthesis. This action results in the weakening of the bacterial cell wall and ultimately leads to cell lysis and death.

Clinical Uses

Cefoselis is primarily used to treat severe infections caused by susceptible bacteria. These infections include:

• Pneumonia
• Urinary tract infections
• Sepsis
• Skin and soft tissue infections

Pharmacokinetics

Cefoselis is administered intravenously. It has a high affinity for binding to plasma proteins and is primarily excreted unchanged in the urine. The elimination half-life of cefoselis is approximately 1.5 to 2 hours.

Side Effects

Common side effects of cefoselis include:

• Nausea
• Diarrhea
• Rash
• Allergic reactions

Related Pages

• Cephalosporin
• Antibiotic
• Bacterial infection
• Penicillin-binding protein
• Peptidoglycan