Ceftolozane/tazobactam
Ceftolozane/tazobactam is a combination antibiotic used to treat a variety of bacterial infections. It is a combination of ceftolozane, a cephalosporin antibiotic, and tazobactam, a beta-lactamase inhibitor. This combination is used to treat certain types of infections caused by bacteria such as pneumonia, urinary tract infections, and infections of the abdomen.
Medical uses[edit | edit source]
Ceftolozane/tazobactam is used to treat a variety of bacterial infections. It is a combination of two drugs: ceftolozane, which is a cephalosporin antibiotic that works by stopping the growth of bacteria, and tazobactam, which is a beta-lactamase inhibitor that helps to prevent resistance to the antibiotic.
Side effects[edit | edit source]
Common side effects of ceftolozane/tazobactam include nausea, diarrhea, and headache. Serious side effects may include allergic reactions, Clostridium difficile infection, and seizures.
Mechanism of action[edit | edit source]
Ceftolozane works by inhibiting the synthesis of the bacterial cell wall, leading to cell death. Tazobactam works by inhibiting beta-lactamase enzymes, preventing them from breaking down ceftolozane and thus increasing its effectiveness.
History[edit | edit source]
Ceftolozane/tazobactam was approved for medical use in the United States in 2014. It is marketed under the brand name Zerbaxa by Merck & Co.
See also[edit | edit source]
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