Ceftolozane/tazobactam

Ceftolozane/tazobactam is a combination antibiotic used to treat a variety of bacterial infections. It is a combination of ceftolozane, a cephalosporin antibiotic, and tazobactam, a beta-lactamase inhibitor. This combination is used to treat certain types of infections caused by bacteria such as pneumonia, urinary tract infections, and infections of the abdomen.

Medical uses

Ceftolozane/tazobactam is used to treat a variety of bacterial infections. It is a combination of two drugs: ceftolozane, which is a cephalosporin antibiotic that works by stopping the growth of bacteria, and tazobactam, which is a beta-lactamase inhibitor that helps to prevent resistance to the antibiotic.

Side effects

Common side effects of ceftolozane/tazobactam include nausea, diarrhea, and headache. Serious side effects may include allergic reactions, Clostridium difficile infection, and seizures.

Mechanism of action

Ceftolozane works by inhibiting the synthesis of the bacterial cell wall, leading to cell death. Tazobactam works by inhibiting beta-lactamase enzymes, preventing them from breaking down ceftolozane and thus increasing its effectiveness.

History

Ceftolozane/tazobactam was approved for medical use in the United States in 2014. It is marketed under the brand name Zerbaxa by Merck & Co.

See also

• List of antibiotics
• Cephalosporin
• Beta-lactamase inhibitor

• 
  Ceftolozane
• 
  Tazobactam