Celgosivir
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| Legal status | Investigational |
| CAS Number | |
| PubChem | 60734 |
| DrugBank | |
| ChemSpider | 54737 |
| KEGG | |
Celgosivir, in development by Migenix for the treatment of hepatitis C virus (HCV) infection, is an oral prodrug of the natural product castanospermine that inhibits alpha-glucosidase I, an enzyme that plays a critical role in viral maturation by initiating the processing of the N-linked oligosaccharides of viral envelope glycoproteins. Celgosivir is well absorbed in vitro and in vivo, and is rapidly converted to castanospermine. Celgosivir has a novel mechanism of action (preventing the glycosylation of viral proteins by the host), and demonstrates broad antiviral activity in vitro.[1]
Clinical trials[edit | edit source]
Celgosivir is not efficient as a monotherapy for the treatment of HCV, but has demonstrated a synergistic effect in combination with pegylated interferon alfa-2b plus ribavirin, both in vitro and in phase II clinical trials that last up to 1 year in patients with chronic HCV infection. Celgosivir may prove to be a valuable component for combination therapy and may help to prevent the apparition of drug resistance. Long-term toxicity studies are necessary to confirm the safety of celgosivir in humans.[1]
Although generally safe and well tolerated, celgosivir does not seem to reduce viral load or fever burden in patients with dengue fever.[2]
References[edit | edit source]
- ↑ 1.0 1.1 , Celgosivir, an alpha-glucosidase I inhibitor for the potential treatment of HCV infection, Current Opinion in Investigational Drugs, 2009, Vol. 10(Issue: 8), pp. 860–70, PMID: 19649930,
- ↑ , Efficacy and safety of celgosivir in patients with dengue fever (CELADEN): A phase 1b, randomised, double-blind, placebo-controlled, proof-of-concept trial, The Lancet Infectious Diseases, 2014, Vol. 14(Issue: 8), pp. 706, DOI: 10.1016/S1473-3099(14)70730-3, PMID: 24877997,
External links[edit | edit source]
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