Cell line

From WikiMD's Wellness Encyclopedia

Cell line refers to a population of cells derived from a single cell of origin. These cells are grown in a lab and are often genetically identical. Cell lines are used extensively in scientific research to study the effects of drugs and viruses, the function of genes, the behavior of cells, and much more.

History[edit | edit source]

The first human cell line, known as HeLa, was established in 1951 from a cervical cancer patient named Henrietta Lacks. Since then, thousands of cell lines have been developed from various species and tissues.

Types of Cell Lines[edit | edit source]

There are two main types of cell lines: primary cell lines and immortal cell lines.

Primary Cell Lines[edit | edit source]

Primary cell lines are established from tissue taken directly from an organism. These cells are more similar to the cells in the body, but they have a limited lifespan and can only be cultured for a short period of time.

Immortal Cell Lines[edit | edit source]

Immortal cell lines are derived from a primary cell line that has acquired the ability to proliferate indefinitely. This can occur naturally, as in the case of cancer cells, or can be induced artificially.

Uses of Cell Lines[edit | edit source]

Cell lines are used in a wide range of scientific research. They are used to study the biology of cells, the effects of drugs and toxins, the process of infection and replication of viruses, and the function of genes.

Controversies[edit | edit source]

The use of cell lines in research has been the subject of several controversies. These include issues related to consent for the use of human tissues, the reproducibility of research, and the authenticity of cell lines.

See Also[edit | edit source]


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Contributors: Prab R. Tumpati, MD