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Talairach Coordinates are a set of three numbers used to indicate the location of a specific point in the brain. These coordinates are based on a brain atlas developed by Jean Talairach and Pierre Tournoux. The Talairach Coordinates system is widely used in neuroimaging studies to report the location of activation foci.

Overview[edit | edit source]

The Talairach Atlas was developed in the 1960s and 1970s by Jean Talairach and Pierre Tournoux at the Sainte-Anne Hospital Center in Paris, France. The atlas is based on the post-mortem examination of a single 60-year-old French woman's brain. The brain was cut into 2mm slices and photographed, and these images were used to create a three-dimensional grid system. This grid system is the basis of the Talairach Coordinates.

Use in Neuroimaging[edit | edit source]

In neuroimaging studies, the Talairach Coordinates are used to report the location of activation foci. The coordinates are given as a set of three numbers, representing the distance (in millimeters) from the Anterior Commissure (AC) in the left-right (x), anterior-posterior (y), and inferior-superior (z) directions. The AC is used as the origin of the coordinate system because it is a clearly visible landmark in MRI images.

Criticisms and Limitations[edit | edit source]

Despite its widespread use, the Talairach Coordinate system has been criticized for several reasons. First, it is based on the brain of a single individual, and there is considerable variability in brain anatomy between individuals. Second, the original Talairach Atlas was based on post-mortem tissue, which can differ in appearance from living tissue. Finally, the atlas is based on 2D images, which can be difficult to align with 3D MRI data.

References[edit | edit source]

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