Chromatin variant
A chromatin variant corresponds to a section of the genome that differs in chromatin states across cell types within an individual (intra-individual) or between individuals for a given cell type (inter-individual). Chromatin variants distinguish DNA sequences that are ON or OFF in any given cell type found in normal or disease tissue. Chromatin variants range in sizes. The smallest chromatin variants cover a few hundred DNA base pairs, such as seen at promoters, enhancers or insulators. The largest chromatin variants capture a few thousand DNA base pairs, such as seen at Large Organized Chromatin Lysine domains (LOCKs) and Clusters Of Cis-Regulatory Elements (COREs), such as super-enhancer.
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