Chrysophanol

Chrysophanol is a naturally occurring anthraquinone present in Rhubarb, Aloe, and Polygonaceae. It is also known as 1,8-dihydroxy-3-methylanthraquinone.

Chemical Properties

Chrysophanol is a yellow crystalline compound with the molecular formula C15H10O4. It is soluble in alcohol and ether, and slightly soluble in water. It has a melting point of 196-198°C.

Biological Activity

Chrysophanol has been found to have several biological activities, including anti-inflammatory, anti-oxidant, anti-cancer, and anti-viral effects. It has been used in traditional medicine for the treatment of various diseases, including constipation, inflammation, and cancer.

Anti-inflammatory Activity

Chrysophanol has been shown to inhibit the production of pro-inflammatory cytokines, such as IL-6 and TNF-α, in various cell types. This suggests that it may have potential as a therapeutic agent for inflammatory diseases.

Anti-oxidant Activity

Chrysophanol has been found to have strong anti-oxidant activity, which may be due to its ability to scavenge free radicals and inhibit lipid peroxidation.

Anti-cancer Activity

Several studies have shown that chrysophanol has anti-cancer effects against various types of cancer cells, including breast, lung, and colon cancer cells. It has been found to induce apoptosis, or programmed cell death, in these cells.

Anti-viral Activity

Chrysophanol has been found to have anti-viral activity against several viruses, including HBV and HSV.

Safety

Chrysophanol is generally considered safe when used in appropriate doses. However, high doses can cause side effects such as nausea, vomiting, and diarrhea. It can also cause skin irritation when applied topically.

See Also

• Anthraquinone
• Rhubarb
• Aloe

Chrysophanol Resources
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