Clavulanate potassium
Clavulanate potassium is a beta-lactamase inhibitor that is frequently combined with penicillin group antibiotics to overcome antibiotic resistance. It is a key component in several widely used antibiotics, including amoxicillin/clavulanate (Augmentin) and ticarcillin/clavulanate (Timentin).
Chemistry[edit | edit source]
Clavulanate potassium is a potassium salt that is derived from clavulanic acid. It is structurally similar to the penicillins, which allows it to bind to beta-lactamase enzymes and inhibit their activity. This prevents the enzymes from breaking down the penicillin antibiotic, thereby allowing the antibiotic to effectively kill the bacteria.
Medical uses[edit | edit source]
Clavulanate potassium is not an antibiotic itself, but it is used in combination with antibiotics to treat a variety of bacterial infections. These include respiratory tract infections, urinary tract infections, skin infections, and sinusitis. It is particularly effective against bacteria that produce beta-lactamase enzymes, which are often resistant to penicillin antibiotics.
Side effects[edit | edit source]
Like all medications, clavulanate potassium can cause side effects. The most common side effects are gastrointestinal, including nausea, vomiting, and diarrhea. Less common side effects include rash, hives, and anaphylaxis, a severe allergic reaction.
See also[edit | edit source]
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