Co-danthrusate

Co-danthrusate is a medication that is commonly used to treat constipation. It is a combination of two active ingredients: danthron and poloxamer 188, which work together to soften the stools and stimulate the bowel muscles to push the stools out.

Mechanism of Action

Co-danthrusate works by two main mechanisms. The danthron component is a stimulant laxative that works by increasing the activity of the intestines and causing the muscles in the bowel wall to contract more often and with increased force. This helps to move the stools through the colon to the rectum so they can be excreted.

The poloxamer 188 component is a stool softener that works by increasing the amount of water the stool absorbs in the gut, making the stool softer and easier to pass.

Uses

Co-danthrusate is primarily used to treat constipation, particularly when lifestyle changes such as increased dietary fibre and fluid intake, and regular exercise, have not been successful. It may also be used to prevent constipation in patients who are taking certain medications that can cause constipation, such as opioids, or in patients with certain medical conditions that can cause constipation, such as Parkinson's disease.

Side Effects

Like all medications, co-danthrusate can cause side effects, although not everyone will experience them. Common side effects include abdominal cramps or discomfort, diarrhoea, and nausea. Less common side effects can include skin rash, urine discoloration, and electrolyte imbalance.

Contraindications

Co-danthrusate should not be used in people who are allergic to danthron or poloxamer 188, or any of the other ingredients in the medication. It should also not be used in people with certain medical conditions, such as intestinal obstruction, acute inflammatory bowel disease, or severe dehydration.

Interactions

Co-danthrusate can interact with certain other medications, including some types of heart medications, diuretics, and other laxatives. It is important to tell your healthcare provider about all the medications you are taking before starting treatment with co-danthrusate.

See Also

• Laxatives
• Constipation
• Danthron
• Poloxamer 188