Coinduction (anaesthetics)

Coinduction (anaesthetics) is a term used in the field of anaesthesiology to describe the process of using multiple anaesthetic agents to induce anaesthesia. This technique is often employed to take advantage of the synergistic effects of different anaesthetic agents, thereby reducing the dose of each individual agent and potentially minimizing their side effects.

History

The concept of coinduction was first introduced in the mid-20th century, as anaesthesiologists began to explore the benefits of using multiple anaesthetic agents. This was a significant departure from the traditional approach of using a single agent, and it has since become a standard practice in many clinical settings.

Technique

Coinduction typically involves the use of two or more anaesthetic agents, each with different pharmacological properties. The choice of agents depends on a variety of factors, including the patient's medical history, the nature of the procedure, and the anaesthesiologist's personal preference.

Commonly used agents for coinduction include propofol, midazolam, and fentanyl. These agents are often administered in a sequential manner, with the aim of achieving a smooth and rapid induction of anaesthesia.

Advantages

The primary advantage of coinduction is that it allows for a reduction in the dose of each individual anaesthetic agent. This can help to minimize the risk of side effects, such as respiratory depression, hypotension, and postoperative nausea and vomiting.

In addition, the use of multiple agents can provide a more balanced anaesthetic effect, with improved analgesia and amnesia.

Disadvantages

Despite its advantages, coinduction is not without its drawbacks. The use of multiple agents can increase the complexity of the anaesthetic procedure, and it requires a thorough understanding of the pharmacology of each agent.

Furthermore, the synergistic effects of the agents can be unpredictable, and there is a risk of drug interactions.

See also

• Anaesthesia
• Anaesthetic agent
• Propofol
• Midazolam
• Fentanyl