Compounding

Overview of pharmaceutical compounding

Overview

A historical depiction of a drug clerk compounding medications.

Compounding is the process of combining, mixing, or altering ingredients to create a medication tailored to the needs of an individual patient. This practice is performed by a licensed pharmacist or a licensed physician. Compounding is a fundamental aspect of pharmacy practice and allows for the customization of medications that are not commercially available.

History

Compounding has been a part of healthcare since the origins of pharmacy. Historically, pharmacists were known as "apothecaries" and were responsible for preparing and dispensing medications. The image to the right depicts a drug clerk from the early 20th century, illustrating the long-standing tradition of compounding in pharmacy practice.

Types of Compounding

Compounding can be categorized into several types, including:

• Non-sterile compounding: This involves the preparation of medications that are not required to be sterile, such as oral capsules, topical creams, and ointments.
• Sterile compounding: This involves the preparation of medications that must be free from microbial contamination, such as intravenous solutions and injections.
• Veterinary compounding: This involves the preparation of medications specifically for animals, taking into account species-specific needs and preferences.

Importance in Modern Medicine

Compounding plays a crucial role in modern medicine by providing solutions for patients with unique needs, such as:

• Patients requiring a specific dosage or strength not available in commercial products.
• Patients with allergies to certain excipients or preservatives found in mass-produced medications.
• Pediatric or geriatric patients who may need medications in a different form, such as a liquid instead of a tablet.

Regulatory Aspects

Compounding is regulated by various national and international bodies to ensure safety and efficacy. In the United States, the Food and Drug Administration (FDA) and state boards of pharmacy oversee compounding practices. Compounded medications are not FDA-approved, but they must be prepared in compliance with applicable standards and regulations.

Challenges and Considerations

Pharmacists involved in compounding must consider several factors, including:

• Ensuring the stability and compatibility of compounded formulations.
• Maintaining a sterile environment for sterile compounding.
• Adhering to strict quality control measures to ensure patient safety.

Related pages

• Pharmacy
• Pharmacist
• Pharmaceutical drug
• Drug formulation