Conditioned compensatory response

Conditioned compensatory response (CR) is an automatic response that is opposite to the effect of alcohol or substance usage. Conditioned behavior is a key part of substance addiction. This response has many implications. For instance, a drug user will be most tolerant to the drug in the presence of cues that have been associated with it, because such cues elicit compensatory responses. As a result, overdose is usually not due to an increase in dosage, but due to taking the drug in a new place without the familiar cues, which would have otherwise allowed the user to tolerate the drug. CR includes a heightened pain sensitivity, and decreased body temperature, and might cause discomfort, thus motivating the drug user to continue usage of the drug. This is one of several ways classical condit

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