Cord colitis syndrome

Cord colitis syndrome is a medical condition that occurs in patients who have undergone umbilical cord blood transplantation. This syndrome is characterized by gastrointestinal symptoms, including diarrhea, abdominal pain, and fever. It is a relatively newly recognized condition, first described in 2011.

Etiology

The exact cause of cord colitis syndrome is not fully understood. However, it is believed to be related to the immune system's response to the transplanted umbilical cord blood. The condition is thought to be a form of graft-versus-host disease (GVHD), where the donor's immune cells attack the recipient's body tissues.

Symptoms

Patients with cord colitis syndrome typically present with:

• Diarrhea
• Abdominal pain
• Fever
• Weight loss
• Nausea and vomiting

Diagnosis

The diagnosis of cord colitis syndrome is primarily clinical, based on the patient's history of umbilical cord blood transplantation and the presence of characteristic symptoms. Endoscopy and biopsy of the gastrointestinal tract may be performed to rule out other causes of the symptoms and to confirm the diagnosis.

Treatment

Treatment for cord colitis syndrome often involves the use of antibiotics and immunosuppressive drugs. The specific choice of medication may vary depending on the severity of the symptoms and the patient's overall health. Commonly used antibiotics include metronidazole and ciprofloxacin.

Prognosis

The prognosis for patients with cord colitis syndrome varies. Some patients respond well to treatment and experience a complete resolution of symptoms, while others may have a more chronic course. Early diagnosis and appropriate treatment are crucial for improving outcomes.

Related Pages

• Umbilical cord blood transplantation
• Graft-versus-host disease
• Immune system
• Gastrointestinal tract
• Endoscopy
• Antibiotics