Cord colitis syndrome
Cord colitis syndrome is a diarrheal illness in recipients of umbilical cord blood transplant. It causes a granulomatous inflammation of the upper and lower gastrointestinal tract and responds to antimicrobial treatment including metronidazole.[1] It was first described in 2011.[2] In 2013, a sequencing study identified a newly discovered bacterium, called Bradyrhizobium enterica, in biopsy samples from two patients. That this bacterium is responsible for this syndrome can be suggested, but not yet confirmed.[3] Subsequent studies showing that Bradyrhizobium species are common contaminants of laboratory kit reagents have thrown this connection into doubt.[4]
Diagnosis[edit | edit source]
The presence of enterica in the colon-biopsy samples has been suggested to help in identification of patients with cord colitis.[5] However, this may be an erroneous report confounded by contamination, and others have not detected Bradyrhizobium in cord colitis samples.[6]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
