Corticotropin

Corticotropin is a hormone produced by the pituitary gland. It is also known as adrenocorticotropic hormone (ACTH). This hormone stimulates the adrenal glands to release cortisol, a steroid hormone that helps the body respond to stress.

Function

Corticotropin is part of the body's response to physical or emotional stress. The hypothalamus, a part of the brain, releases corticotropin-releasing hormone (CRH) when it detects stress. CRH then triggers the pituitary gland to produce and release corticotropin. Once released into the bloodstream, corticotropin travels to the adrenal glands, where it stimulates the release of cortisol.

Cortisol has many functions in the body. It helps to maintain blood pressure and cardiovascular function, reduce the immune system's response to inflammation, balance the effects of insulin in breaking down sugar for energy, and regulate the metabolism of proteins, carbohydrates, and fats.

Disorders related to Corticotropin

Disorders related to corticotropin include Cushing's syndrome, Addison's disease, and Adrenal insufficiency. These disorders can occur if the body produces too much or too little corticotropin.

Cushing's syndrome is a condition that occurs when the body produces too much cortisol. This can occur if the pituitary gland produces too much corticotropin. Symptoms of Cushing's syndrome can include weight gain, thinning skin, and fatigue.

Addison's disease is a condition that occurs when the body does not produce enough cortisol. This can occur if the pituitary gland does not produce enough corticotropin. Symptoms of Addison's disease can include weight loss, muscle weakness, and low blood pressure.

Adrenal insufficiency is a condition that occurs when the adrenal glands do not produce enough cortisol. This can occur if the pituitary gland does not produce enough corticotropin. Symptoms of adrenal insufficiency can include fatigue, muscle weakness, and low blood pressure.

See also

• Pituitary gland
• Adrenal gland
• Cortisol
• Cushing's syndrome
• Addison's disease
• Adrenal insufficiency

Corticotropin Resources
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