Cotrimoxazole

Cotrimoxazole is a combination of two antibacterial medications, trimethoprim and sulfamethoxazole. It is used to treat a variety of bacterial infections, including urinary tract infections, bronchitis, and pneumonia.

Uses

Cotrimoxazole is used to treat a variety of bacterial infections. It is particularly effective against Gram-negative bacteria, including Escherichia coli, Klebsiella species, and Proteus species. It is also used to treat Gram-positive bacteria, such as Staphylococcus species and Streptococcus species.

In addition to treating infections, cotrimoxazole is also used as a preventative measure in people with weakened immune systems, such as those with HIV/AIDS or those undergoing chemotherapy.

Mechanism of Action

Cotrimoxazole works by inhibiting the production of folic acid in bacteria. Folic acid is essential for the bacteria to reproduce and grow. By inhibiting its production, cotrimoxazole prevents the bacteria from growing and spreading, allowing the body's immune system to eliminate the infection.

Side Effects

Like all medications, cotrimoxazole can cause side effects. Common side effects include nausea, vomiting, and diarrhea. Less common but more serious side effects can include skin rash, fever, and anemia.

Precautions

Before taking cotrimoxazole, it is important to inform your doctor if you have any allergies, especially to sulfa drugs or trimethoprim. It is also important to inform your doctor if you have a history of kidney disease, liver disease, or folic acid deficiency.

See Also

• Antibiotics
• Bacterial Infections
• Urinary Tract Infections
• Bronchitis
• Pneumonia

Cotrimoxazole Resources
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