Lotilaner

Lotilaner is a insecticide and acaricide that is used in veterinary medicine to treat and prevent flea and tick infestations in dogs and cats. It is a member of the isoxazoline group of chemicals, which are known for their insecticidal and acaricidal properties. Lotilaner works by inhibiting the gamma-aminobutyric acid (GABA)-gated chloride channels in the nervous system of insects and acarids, causing uncontrolled activity and death.

Uses

Lotilaner is used in veterinary medicine to treat and prevent flea and tick infestations in dogs and cats. It is administered orally and begins to kill fleas within 30 minutes of administration, and ticks within 24 hours. It continues to be effective for one month after administration.

Mechanism of Action

Lotilaner is a member of the isoxazoline group of chemicals, which are known for their insecticidal and acaricidal properties. It works by inhibiting the GABA-gated chloride channels in the nervous system of insects and acarids. This causes uncontrolled activity in the nervous system, leading to death of the insect or acarid.

Side Effects

The most common side effects of lotilaner in dogs and cats are vomiting, diarrhea, and lack of appetite. In rare cases, it can cause neurological side effects such as tremors, ataxia, and seizures.

Precautions

Lotilaner should not be used in dogs or cats with a known hypersensitivity to isoxazoline class drugs. It should be used with caution in dogs and cats with a history of seizures or neurological disorders.

References

• [European Medicines Agency - Credelio (lotilaner)]
• [FDA - Fact Sheet for Pet Owners and Veterinarians about Potential Adverse Events Associated with Isoxazoline Flea and Tick Products]

Lotilaner Resources
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