Kolliphor EL
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Kolliphor EL is a pharmaceutical excipient commonly used in the formulation of various medications. It is a nonionic surfactant that belongs to the class of polyoxyethylene derivatives of fatty acids. Kolliphor EL is known for its emulsifying and solubilizing properties, making it a versatile ingredient in pharmaceutical formulations.
Properties[edit | edit source]
Kolliphor EL is a clear, colorless to pale yellow liquid at room temperature. It is soluble in water and miscible with most organic solvents. The chemical structure of Kolliphor EL consists of a hydrophilic polyethylene glycol chain attached to a lipophilic fatty acid chain. This unique structure allows Kolliphor EL to act as a surfactant, reducing the surface tension between immiscible liquids and aiding in the formation of stable emulsions.
Uses[edit | edit source]
Kolliphor EL is commonly used in pharmaceutical formulations to improve the solubility and bioavailability of poorly water-soluble drugs. It is often employed in oral, topical, and parenteral dosage forms such as emulsions, microemulsions, and self-emulsifying drug delivery systems. Kolliphor EL can enhance the absorption of lipophilic drugs by promoting their dispersion in aqueous media, thereby increasing their therapeutic efficacy.
Safety[edit | edit source]
Kolliphor EL is generally regarded as safe for use in pharmaceuticals when used in accordance with good manufacturing practices. However, like all excipients, it may cause adverse effects in some individuals, particularly in cases of hypersensitivity or allergic reactions. It is important for formulators to consider the potential risks associated with Kolliphor EL and conduct appropriate safety assessments before incorporating it into drug products.
References[edit | edit source]
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