Cunningham

Cunningham is a term that has various meanings in different contexts. In the medical field, it is often associated with the Cunningham Panel, a series of tests used to help diagnose PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections) and PANS (Pediatric Acute-onset Neuropsychiatric Syndrome).

Cunningham Panel

The Cunningham Panel is a set of five tests that measure the levels of antibodies in the blood and the capability of these antibodies to stimulate a particular type of cell (called a neuron) in the brain. This panel was developed by Dr. Madeleine Cunningham, hence the name.

The panel includes the following tests:

• Anti-Dopamine D1 Receptor (DRD1) IgG
• Anti-Dopamine D2L Receptor (DRD2L) IgG
• Anti-Lysoganglioside-GM1 IgG
• Anti-Tubulin IgG
• CaMKII (Calcium/calmodulin-dependent protein kinase II) Activation

Clinical Significance

The Cunningham Panel is used to assist in the diagnosis of PANDAS and PANS, conditions that occur in children and are characterized by a sudden onset of symptoms such as OCD (Obsessive Compulsive Disorder) and tics following a strep infection. The panel is not a definitive diagnostic tool but is used in conjunction with other clinical assessments.

Limitations

While the Cunningham Panel can provide valuable information, it has limitations. It is not a standalone diagnostic tool and should be used in conjunction with other clinical assessments. Additionally, the panel does not provide information about the severity of the condition or the best course of treatment.

See Also

• PANDAS
• PANS
• Obsessive Compulsive Disorder
• Tics

Cunningham Resources
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