Cupiennin

Cupiennin is a family of peptides found in the venom of the Cupiennius salei spider. These peptides are known for their potent antimicrobial and cytolytic properties, making them a subject of interest in the field of biomedical research.

Overview

Cupiennin peptides are small, cationic, and amphipathic, characteristics that allow them to interact with and disrupt cell membranes. They are primarily composed of 35-40 amino acid residues and are rich in lysine and hydrophobic amino acids.

Biological Activity

Cupiennin peptides exhibit a broad spectrum of antimicrobial activity against both Gram-positive and Gram-negative bacteria, as well as fungi. They are also cytolytic, meaning they can cause the rupture and death of various types of cells, including cancer cells.

Potential Applications

Due to their antimicrobial and cytolytic properties, Cupiennin peptides are being studied for potential use in the development of new antibiotics and cancer treatments.

See Also

• Arachnid venom
• Antimicrobial peptides
• Cytolysis

References

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