DEFB106A

Ideogram human chromosome 8

DEFB106A

DEFB106A is a gene that encodes for a defensin protein in humans. Defensins are small peptides that play a crucial role in the innate immune system by defending against microbial infections. The DEFB106A gene is located on chromosome 8 in humans.

Function

The protein encoded by DEFB106A belongs to the beta-defensin family, which are antimicrobial peptides that act as a first line of defense against pathogens. Beta-defensins are known for their ability to disrupt the cell membranes of bacteria, fungi, and viruses, thereby inhibiting their growth and survival.

Expression

DEFB106A is primarily expressed in the epithelial cells of various tissues, including the skin, respiratory tract, and gastrointestinal tract. The expression of DEFB106A is upregulated in response to microbial infections or inflammatory stimuli, highlighting its role in host defense mechanisms.

Role in Immunity

The defensin protein produced by DEFB106A exhibits broad-spectrum antimicrobial activity, targeting a wide range of pathogens. By disrupting the integrity of microbial cell membranes, defensins help to neutralize invading microorganisms and prevent infection.

Clinical Significance

Mutations or dysregulation of the DEFB106A gene have been associated with certain inflammatory skin conditions and infectious diseases. Understanding the function of DEFB106A and its role in immunity may provide insights into potential therapeutic strategies for combating microbial infections.

See also

• Defensin
• Innate immune system
• Antimicrobial peptides