DR1

DR1 (also known as Down-regulator of transcription 1, NC2alpha or Dr1 ) is a protein that in humans is encoded by the DR1 gene. It is a TBP (TATA binding protein)-associated phosphoprotein that inhibits both RNA polymerase II and III-dependent transcription.

Function

The protein encoded by the DR1 gene is a component of the transcription regulatory complex Negative cofactor 2 (NC2). It is known to down-regulate transcription by binding to the TATA-binding protein (TBP) and inhibiting the activity of RNA polymerase II and RNA polymerase III. This protein is highly conserved across species, suggesting its crucial role in the regulation of transcription.

Clinical significance

Mutations in the DR1 gene have been associated with various diseases, including cancer. The exact mechanisms by which these mutations contribute to disease development and progression are still under investigation.

Interactions

DR1 has been shown to interact with:

• TATA binding protein
• Negative cofactor 2
• DRAP1

See also

• Transcription (genetics)
• Gene expression
• Protein-protein interaction

External links

• DR1 at the US National Library of Medicine Medical Subject Headings (MeSH)

DR1 Resources
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