DRD1

DRD1 is a G protein-coupled receptor that is associated with the dopamine neurotransmitter. It is encoded by the DRD1 gene in humans. Dopamine receptor D1, also known as DRD1, is one of the five main dopamine receptors. Dopamine receptors are responsible for many functions in the body and brain, including the regulation of mood, motivation, and reward, as well as the mediation of the smooth muscle movement of the gastrointestinal tract.

Function

The DRD1 gene is a G protein-coupled receptor that stimulates adenylyl cyclase. It is a receptor for dopamine, a neurotransmitter that is produced in several areas of the brain, including the substantia nigra. Dopamine receptors are involved in many neurological processes, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as modulation of neuroendocrine signaling. Abnormal dopamine receptor signaling and dopaminergic nerve function is associated with several neuropsychiatric disorders. Thus, dopamine receptors are common neurologic drug targets.

Clinical significance

Alterations in the function of the DRD1 gene have been associated with several neuropsychiatric disorders. For example, a polymorphism in the DRD1 gene was associated with nicotine dependence, where the presence of the A allele was associated with an increased risk of nicotine dependence. In addition, variations in the DRD1 gene have been associated with an increased risk of developing Parkinson's disease.

See also

• Dopamine receptor
• Dopamine
• G protein-coupled receptor
• Neurotransmitter
• Parkinson's disease

External links

• DRD1 at the US National Library of Medicine Medical Subject Headings (MeSH)

DRD1 Resources
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