DRD1

DRD1 is a G protein-coupled receptor that is associated with the dopamine neurotransmitter. It is encoded by the DRD1 gene in humans. Dopamine receptor D1, also known as DRD1, is one of the five main dopamine receptors. Dopamine receptors are responsible for many functions in the body and brain, including the regulation of mood, motivation, and reward, as well as the mediation of the smooth muscle movement of the gastrointestinal tract.

Function[edit | edit source]

The DRD1 gene is a G protein-coupled receptor that stimulates adenylyl cyclase. It is a receptor for dopamine, a neurotransmitter that is produced in several areas of the brain, including the substantia nigra. Dopamine receptors are involved in many neurological processes, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as modulation of neuroendocrine signaling. Abnormal dopamine receptor signaling and dopaminergic nerve function is associated with several neuropsychiatric disorders. Thus, dopamine receptors are common neurologic drug targets.

Clinical significance[edit | edit source]

Alterations in the function of the DRD1 gene have been associated with several neuropsychiatric disorders. For example, a polymorphism in the DRD1 gene was associated with nicotine dependence, where the presence of the A allele was associated with an increased risk of nicotine dependence. In addition, variations in the DRD1 gene have been associated with an increased risk of developing Parkinson's disease.

References[edit | edit source]

External links[edit | edit source]

DRD1 at the US National Library of Medicine Medical Subject Headings (MeSH)

DRD1 Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.