DRD3

DRD3 or Dopamine receptor D3 is a protein that is encoded by the DRD3 gene in humans. It is a member of the dopamine receptor family, which are G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS).

Function

The dopamine receptor D3, also known as DRD3, is a subtype of the dopamine receptor that has a high affinity for dopamine. It is primarily expressed in the islands of Calleja and the nucleus accumbens of the brain. The DRD3 is involved in a variety of functions, including locomotion, pleasure, and reward, as well as cognitive processes such as learning and memory.

Clinical significance

Alterations in the function or expression of the DRD3 gene have been associated with a variety of psychiatric disorders, including schizophrenia, bipolar disorder, and addiction. In addition, polymorphisms in this gene have been associated with susceptibility to Restless Legs Syndrome and Parkinson's disease.

Pharmacology

The DRD3 receptor is a target for several types of drugs, including antipsychotics and antiparkinsonian drugs. Some of these drugs, such as pramipexole and ropinirole, are used to treat Parkinson's disease, while others, such as clozapine and quetiapine, are used to treat schizophrenia and bipolar disorder.

See also

• Dopamine receptor
• Dopamine receptor D2
• Dopamine receptor D4

References

DRD3 Resources
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