DVL1

Protein DVL1 PDB 1fsh

DVL1

Dishevelled segment polarity protein 1 (DVL1) is a protein that in humans is encoded by the DVL1 gene. DVL1 is a member of the Dishevelled family and plays a crucial role in the Wnt signaling pathway.

Structure

DVL1 consists of three domains: DIX domain, PDZ domain, and DEP domain. These domains are essential for its function in transducing the Wnt signal.

Function

DVL1 acts as a key mediator in the Wnt signaling pathway by transducing the signal from the cell surface receptor to the nucleus. It regulates various cellular processes such as cell proliferation, differentiation, and migration.

Clinical Significance

Mutations in the DVL1 gene have been associated with various diseases, including cancer and developmental disorders. Dysregulation of the Wnt signaling pathway due to abnormal DVL1 function can lead to tumorigenesis and other pathological conditions.

Interactions

DVL1 interacts with several proteins involved in the Wnt signaling pathway, such as Frizzled receptors and β-catenin. These interactions are crucial for the proper transmission of the Wnt signal within the cell.

Regulation

The activity of DVL1 is tightly regulated by various mechanisms, including phosphorylation and protein degradation. These regulatory processes ensure the precise control of Wnt signaling in normal cellular functions.