DecodeME

DecodeME is a large-scale DNA study aimed at understanding Myalgic Encephalomyelitis (ME), also known as Chronic Fatigue Syndrome (CFS). The study is a collaboration between the UK Biobank, the ME Association, Action for ME, and the CureME biobank at the London School of Hygiene and Tropical Medicine. The project is funded by the Medical Research Council and the National Institute for Health Research.

Overview

The DecodeME study aims to recruit 20,000 people with ME/CFS in the UK to provide saliva samples for DNA analysis. The goal is to identify genetic factors that may make people susceptible to developing ME/CFS, and to understand more about the disease's underlying biology. The study is the largest of its kind in the world and is expected to significantly advance our understanding of ME/CFS.

Methodology

Participants in the DecodeME study are asked to provide a saliva sample, which is then analyzed for genetic information. The researchers use a technique called genome-wide association study (GWAS) to compare the DNA of people with ME/CFS with the DNA of people without the disease. This allows them to identify any genetic differences that may be associated with ME/CFS.

Significance

The DecodeME study is significant because it is the largest genetic study of ME/CFS to date. The results of the study could lead to a better understanding of the disease, which could in turn lead to improved diagnosis and treatment options. The study could also help to dispel some of the stigma associated with ME/CFS, by providing concrete evidence of its biological basis.

See also

• Myalgic Encephalomyelitis
• Chronic Fatigue Syndrome
• Genome-wide association study
• UK Biobank

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