Delmadinone acetate

Delmadinone acetate is a synthetic steroidal progestin that is used in veterinary medicine for its antiandrogenic and progestogenic effects. It is primarily utilized in the treatment of conditions related to hormonal imbalances in animals, such as benign prostatic hyperplasia (BPH), certain forms of dermatitis, and to control estrus in female animals.

Pharmacology

Delmadinone acetate acts by binding to the progesterone and androgen receptors, inhibiting the effects of endogenous androgens. Its mechanism of action involves the suppression of gonadotropin secretion, which leads to a decrease in testosterone levels in males and estradiol in females, thereby mitigating the symptoms associated with hormonal imbalances.

Uses

Delmadinone acetate is used in veterinary medicine for several purposes:

• Benign Prostatic Hyperplasia (BPH): In male animals, particularly dogs, delmadinone acetate is used to reduce the size of the prostate gland and alleviate the symptoms of BPH.
• Dermatitis: It is employed in the treatment of certain forms of dermatitis that are responsive to hormonal therapy.
• Estrus Control: In female animals, delmadinone acetate is used to control estrus cycles, making it useful for breeders who wish to manage the breeding periods of their animals.

Administration and Dosage

Delmadinone acetate is administered either orally or by injection, depending on the condition being treated and the species of the animal. The dosage and duration of treatment are determined based on the specific needs of the animal, taking into account factors such as weight, age, and the severity of the condition.

Side Effects

As with all medications, delmadinone acetate can cause side effects, although not all animals will experience them. Potential side effects include:

• Gastrointestinal disturbances
• Changes in behavior
• Weight gain
• Temporary infertility in both male and female animals

Veterinarians should evaluate the risks and benefits of treatment with delmadinone acetate on an individual basis.

Contraindications

Delmadinone acetate should not be used in animals with known hypersensitivity to the drug. It is also contraindicated in pregnant animals due to the potential for causing fetal harm.

Pharmacokinetics

The pharmacokinetics of delmadinone acetate, including its absorption, distribution, metabolism, and excretion, vary among different animal species. Generally, the drug is well-absorbed and metabolized in the liver, with the metabolites being excreted primarily in the urine.

Regulatory Status

The regulatory status of delmadinone acetate varies by country. In some jurisdictions, it is available only by prescription from a licensed veterinarian, while in others, it may be subject to more stringent controls.