Penciclovir

Penciclovir is an antiviral medication used to treat herpes simplex virus infections. It is a guanosine analogue and a nucleoside analogue. It is primarily used in the treatment of herpes labialis (cold sores) and herpes zoster (shingles).

Mechanism of Action

Penciclovir works by inhibiting the replication of the herpes simplex virus. It is converted into a triphosphate form in the infected cells which inhibits the viral DNA polymerase, thereby preventing the virus from multiplying.

Pharmacokinetics

After topical application, penciclovir is absorbed into the skin where it is converted into its active form. It has a half-life of 2 hours and is excreted in the urine.

Side Effects

Common side effects of penciclovir include nausea, headache, and rash. In rare cases, it can cause serious side effects such as anaphylaxis and angioedema.

Interactions

Penciclovir can interact with other antiviral medications such as acyclovir and ganciclovir. It can also interact with probenecid, a medication used to treat gout.

Contraindications

Penciclovir is contraindicated in patients with known hypersensitivity to penciclovir or any of its components.

See Also

• Famciclovir
• Valacyclovir
• Antiviral drug

Penciclovir Resources
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