Deplin

Medical food used to treat depression

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Deplin

Drug Information
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Deplin is a medical food used to manage depression and folate deficiency. It contains L-methylfolate, the active form of folate, which is a B-vitamin essential for neurotransmitter synthesis and mood regulation.

Medical Uses

Deplin is primarily prescribed for patients with major depressive disorder (MDD) who have a folate deficiency. It is often used as an adjunctive treatment to enhance the effectiveness of antidepressant medications. By providing the active form of folate, Deplin helps in the synthesis of serotonin, dopamine, and norepinephrine, which are crucial for mood stabilization.

Mechanism of Action

L-methylfolate, the active ingredient in Deplin, bypasses the MTHFR (methylenetetrahydrofolate reductase) enzyme, which is necessary for converting folic acid into its active form. This is particularly beneficial for individuals with MTHFR gene mutations, who may have difficulty converting folic acid to L-methylfolate. By directly providing L-methylfolate, Deplin supports the production of neurotransmitters involved in mood regulation.

Dosage and Administration

Deplin is available in tablet form and is typically taken once daily. The dosage may vary depending on the patient's condition and response to treatment. It is important to follow the prescribing healthcare provider's instructions.

Side Effects

Common side effects of Deplin may include nausea, insomnia, and irritability. Severe side effects are rare but can include allergic reactions such as rash, itching, and swelling.

Related Pages

• Depression (mood)
• Folate
• Antidepressant
• Neurotransmitter
• MTHFR
• Major depressive disorder

See Also

• Medical food
• B-vitamin
• Mood stabilizer