Desacetylmetipranolol

Desacetylmetipranolol is a primary active metabolite of the beta blocker drug metipranolol. It is formed in the body after administration of metipranolol, through the process of metabolism.

Pharmacology

Desacetylmetipranolol, like metipranolol, is a non-selective beta blocker. This means it blocks both beta-1 and beta-2 receptors. Beta-1 receptors are primarily located in the heart and kidneys, while beta-2 receptors are found in the lungs, liver, and vascular smooth muscle. By blocking these receptors, desacetylmetipranolol can reduce heart rate, decrease blood pressure, and lower stress on the heart.

Clinical Use

Desacetylmetipranolol is not used directly as a medication, but its formation in the body contributes to the therapeutic effects of metipranolol. Metipranolol is used to treat conditions such as hypertension (high blood pressure), angina pectoris (chest pain due to heart disease), and arrhythmia (irregular heartbeat). It is also used in the management of glaucoma, a condition that causes increased pressure in the eyes.

Side Effects

As a beta blocker, desacetylmetipranolol can cause a range of side effects. These may include fatigue, cold hands and feet, slow heartbeat, and sleep disturbances. More serious side effects can include shortness of breath, swelling of the hands or feet, unusual weight gain, or symptoms of heart failure.

See Also

• Metipranolol
• Beta blocker
• Metabolite
• Pharmacology