Desmocollin

Desmocollin is a protein that in humans is encoded by the DSC gene. Desmocollins, along with desmoglein, are cadherin proteins that make up desmosome, a cell structure specialized for cell-to-cell adhesion.

Function

Desmocollin and desmoglein are essential for the function of desmosomes, which are necessary for maintaining the structural integrity of tissues. They are involved in the organization of the intercellular junctions that anchor the intermediate filaments, forming a robust structure that resists mechanical stress.

Structure

Desmocollin is a transmembrane glycoprotein with a molecular weight of approximately 100 kDa. It has a large extracellular domain, a single transmembrane domain, and a smaller intracellular domain. The extracellular domain is responsible for the adhesion function of the protein, while the intracellular domain interacts with other proteins in the desmosome.

Clinical significance

Mutations in the DSC gene can lead to various skin disorders, such as pemphigus, palmoplantar keratoderma, and hair loss.

See also

• Desmoglein
• Desmosome
• Cadherin

External links

• DSC gene at National Center for Biotechnology Information

Desmocollin Resources
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