Dextran 70

Dextran 70 is a high molecular weight polysaccharide that is commonly used in medical and scientific applications. It is produced by certain types of bacteria, including Leuconostoc mesenteroides, through the fermentation of sucrose.

Production

The production of Dextran 70 involves the fermentation of sucrose by the bacterium Leuconostoc mesenteroides. The bacteria produce an enzyme called dextran sucrase, which links together the glucose units from the sucrose to form the dextran polymer. The number "70" in the name refers to the average molecular weight of the dextran in kilodaltons.

Medical Uses

Dextran 70 is used in medicine as a volume expander for hypovolemia, or low blood volume, and to improve blood flow in microvascular surgery. It is also used as an antithrombotic to prevent blood clots. In ophthalmology, it is used as a lubricant in certain eye drops.

Scientific Applications

In scientific research, Dextran 70 is used in a variety of applications. It is used as a stabilizer in protein solutions, and as a spacer in certain types of immunoassays. It is also used in the preparation of microspheres for drug delivery, and as a coating material for medical devices.

Safety and Side Effects

While Dextran 70 is generally considered safe for use in humans, it can cause side effects in some individuals. These can include allergic reactions, changes in blood pressure, and changes in blood clotting times. It can also cause changes in blood chemistry, including increases in blood sugar levels.

See Also

• Dextran
• Polysaccharide
• Volume expander
• Leuconostoc mesenteroides