Diacetylnalorphine

Diacetylnalorphine is a semi-synthetic opioid derived from morphine. It is also known as Paralaudin, and it is a potent analgesic used for the relief of severe pain.

Chemistry

Diacetylnalorphine is a morphine derivative where the 3 and 6 hydroxyl groups have been acetylated. The chemical formula of diacetylnalorphine is C21H23NO5. It is a white crystalline powder that is soluble in water.

Pharmacology

Diacetylnalorphine acts on the mu opioid receptor in the central nervous system, producing analgesia and sedation. It is more potent than morphine and has a faster onset of action. However, it also has a shorter duration of action, which can lead to a higher risk of dependence and addiction.

Medical Use

Diacetylnalorphine is used in the treatment of severe pain, such as that caused by cancer or severe injury. It is usually administered by injection. Due to its high potential for addiction, it is a controlled substance in many countries.

Side Effects

Common side effects of diacetylnalorphine include nausea, vomiting, constipation, and drowsiness. More serious side effects can include respiratory depression, dependence, and overdose.

History

Diacetylnalorphine was first synthesized in the early 20th century as a potential alternative to morphine. However, it was soon found to have a higher potential for addiction and was largely replaced by other opioids.

See Also

• Opioid
• Morphine
• Analgesic
• Addiction