Diazoxide choline

Diazoxide Choline is a pharmaceutical drug that belongs to the class of benzothiadiazine derivatives. It is primarily used in the treatment of hypoglycemia due to its ability to inhibit insulin secretion from the pancreas. Diazoxide Choline is a choline salt of diazoxide, which is a potent vasodilator.

Pharmacology

Diazoxide Choline works by opening ATP-sensitive potassium channels in the beta cells of the pancreatic islets. This leads to hyperpolarization of the cell membrane, which in turn inhibits the release of insulin. The drug also has a direct inhibitory effect on insulin release.

Clinical Use

Diazoxide Choline is used in the management of hypoglycemic conditions, particularly in cases of insulinoma, a rare tumor of the pancreas that produces excessive amounts of insulin. It is also used in the treatment of severe, recurrent hypoglycemia in patients with conditions such as congenital hyperinsulinism.

Side Effects

Common side effects of Diazoxide Choline include fluid retention, hyperglycemia, and hypertension. Less common side effects can include gastrointestinal disturbances, hirsutism, and hyperuricemia.

Contraindications

Diazoxide Choline is contraindicated in patients with known hypersensitivity to the drug or any of its components. It is also contraindicated in patients with compensatory hypertension and those with functional carcinoid tumors.

See Also

• Hypoglycemia
• Insulinoma
• Congenital hyperinsulinism
• Benzothiadiazine