Dimazole
Overview[edit | edit source]
Dimazole is an antifungal medication used primarily in the treatment of fungal infections. It belongs to the class of imidazole antifungals, which work by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes.
Mechanism of Action[edit | edit source]
Dimazole functions by disrupting the production of ergosterol, a critical component of the fungal cell membrane. By inhibiting the enzyme lanosterol 14_-demethylase, dimazole prevents the conversion of lanosterol to ergosterol, leading to increased membrane permeability and ultimately cell death.
Clinical Uses[edit | edit source]
Dimazole is indicated for the treatment of various fungal infections, including:
It is available in several formulations, including topical creams, oral tablets, and intravenous solutions, depending on the severity and location of the infection.
Side Effects[edit | edit source]
Common side effects of dimazole include:
Serious side effects, though rare, may include hepatotoxicity and anaphylaxis. Patients are advised to report any unusual symptoms to their healthcare provider.
Pharmacokinetics[edit | edit source]
Dimazole is well absorbed when administered orally, with peak plasma concentrations occurring within 1-2 hours. It is metabolized in the liver and excreted primarily in the urine.
Contraindications[edit | edit source]
Dimazole is contraindicated in patients with known hypersensitivity to imidazole antifungals. Caution is advised in patients with liver disease due to the potential for hepatotoxicity.
Related Pages[edit | edit source]
Gallery[edit | edit source]
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Contributors: Prab R. Tumpati, MD
