Dimethyltubocurarinium chloride

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Dimethyltubocurarinium chloride (also known as DMT-C or Metubine) is a pharmacological agent classified as a non-depolarizing neuromuscular-blocking drug. It is a derivative of tubocurarine, and is used primarily in the field of anesthesiology.

History[edit | edit source]

Dimethyltubocurarinium chloride was first synthesized in the mid-20th century as a part of a series of modifications to the tubocurarine molecule. The goal was to create a drug with the muscle-relaxing properties of tubocurarine, but with fewer side effects. The result was a compound that was more potent and had a shorter duration of action than its parent compound.

Pharmacology[edit | edit source]

As a non-depolarizing neuromuscular-blocking drug, dimethyltubocurarinium chloride works by blocking the action of acetylcholine, a neurotransmitter that transmits signals in the nervous system. By preventing acetylcholine from binding to its receptors at the neuromuscular junction, dimethyltubocurarinium chloride causes muscle relaxation and paralysis.

Clinical Use[edit | edit source]

In clinical settings, dimethyltubocurarinium chloride is used to induce muscle relaxation during surgery or mechanical ventilation. It is administered intravenously and its effects are usually evident within a few minutes. The duration of action is typically 20-30 minutes, but can be extended if the drug is administered in larger doses or in combination with other drugs.

Side Effects[edit | edit source]

The most common side effects of dimethyltubocurarinium chloride are related to its muscle-relaxing properties and can include weakness, difficulty breathing, and low blood pressure. In rare cases, it can cause an allergic reaction.

See Also[edit | edit source]

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