Dimetofrine

Dimetofrine is a vasoconstrictor and antihypotensive agent that is used in the treatment of hypotension. It is also known as Dimetofrin and Dimetofrine Pantothenate.

Pharmacology[edit | edit source]

Dimetofrine is a synthetic sympathomimetic amine that primarily acts on alpha-adrenergic receptors. It stimulates the sympathetic nervous system, resulting in vasoconstriction. This increases blood pressure by reducing the diameter of blood vessels, which increases the resistance to blood flow.

Medical Uses[edit | edit source]

Dimetofrine is used in the treatment of hypotension, particularly in cases where the condition is caused by shock, anesthesia, or sepsis. It can also be used to treat orthostatic hypotension, a condition where blood pressure drops significantly when a person stands up from a sitting or lying position.

Side Effects[edit | edit source]

Like other sympathomimetic amines, Dimetofrine can cause a number of side effects. These can include palpitations, tachycardia, arrhythmia, and hypertension. In rare cases, it can cause severe cardiovascular events such as myocardial infarction or stroke.

Contraindications[edit | edit source]

Dimetofrine is contraindicated in patients with hypertension, hyperthyroidism, and those with a history of hypersensitivity to sympathomimetic amines. It should also be used with caution in patients with coronary artery disease or other cardiovascular conditions.