Dipeptidyl-peptidase II

Dipeptidyl-peptidase II (DPP II) is an enzyme that plays a crucial role in the metabolism of peptides in the human body. It is a member of the dipeptidyl-peptidase family of enzymes, which are responsible for cleaving dipeptides from the N-terminus of polypeptides. DPP II specifically targets dipeptides with proline or alanine at the N-terminus.

Function

DPP II is primarily found in the cytoplasm of cells, where it acts as an exopeptidase. It cleaves dipeptides from the N-terminus of polypeptides, releasing free amino acids. This process is important for the breakdown of proteins and the recycling of amino acids in the body.

Role in the Immune System

DPP II has been found to play a role in the immune system. It is expressed in various immune cells, including macrophages and dendritic cells. Studies have shown that DPP II can modulate immune responses by influencing the production of cytokines and chemokines. Additionally, DPP II has been implicated in the regulation of T-cell activation and proliferation.

Clinical Significance

DPP II has been investigated as a potential therapeutic target for various diseases. In particular, it has been studied in the context of cancer and autoimmune disorders. In cancer, DPP II has been found to be upregulated in certain tumor types, suggesting a potential role in tumor growth and progression. In autoimmune disorders, DPP II has been implicated in the regulation of immune responses, making it a potential target for therapeutic intervention.