Dithranol

Dithranol

Dithranol chemical structure

Dithranol, also known as anthralin, is a medication used in the treatment of psoriasis and other skin conditions. It is derived from coal tar and has been used for many years due to its effectiveness in reducing the symptoms of psoriasis.

History

Dithranol was first discovered in the early 1900s and was initially used as a dye. However, its therapeutic properties were soon recognized, and it was introduced as a treatment for psoriasis in the 1920s. Since then, it has become one of the most commonly prescribed topical treatments for psoriasis.

Mechanism of Action

Dithranol works by slowing down the growth of skin cells and reducing inflammation. It is thought to inhibit the DNA synthesis in the skin cells, leading to a decrease in their proliferation. This helps to alleviate the symptoms of psoriasis, such as redness, scaling, and itching.

Application and Dosage

Dithranol is typically applied topically to the affected areas of the skin. It is available in various formulations, including creams, ointments, and pastes. The concentration of dithranol in these formulations may vary, and the appropriate dosage should be determined by a healthcare professional.

Side Effects

Common side effects of dithranol include skin irritation, redness, and staining of the skin and clothing. These side effects are usually temporary and resolve once the treatment is discontinued. However, in some cases, dithranol may cause more severe side effects, such as allergic reactions or skin sensitization. It is important to follow the instructions provided by the healthcare professional and report any adverse reactions.

Precautions

Dithranol should not be applied to broken or infected skin, as it may worsen the condition. It is also not recommended for use on the face or genitals. Pregnant or breastfeeding women should consult their healthcare provider before using dithranol.

See Also

• Psoriasis
• Coal tar
• Topical medication