Dolutegravir/emtricitabine/tenofovir alafenamide
Dolutegravir/Emtricitabine/Tenofovir Alafenamide (also known as DTG/FTC/TAF) is a fixed-dose combination antiretroviral medication used in the treatment of HIV/AIDS. It combines three active pharmaceutical ingredients: Dolutegravir, a second-generation integrase inhibitor; Emtricitabine, a nucleoside reverse transcriptase inhibitor (NRTI); and Tenofovir Alafenamide, a prodrug of tenofovir, also an NRTI.
Pharmacology[edit | edit source]
The combination of these three drugs works synergistically to inhibit the replication of the HIV virus. Dolutegravir inhibits the viral enzyme integrase, preventing the integration of the viral genome into the host cell. Emtricitabine and Tenofovir Alafenamide both inhibit the viral enzyme reverse transcriptase, which is necessary for the virus to replicate its RNA into DNA.
Clinical Use[edit | edit source]
DTG/FTC/TAF is used as a first-line treatment for adults and adolescents with HIV-1 infection. It is also used in certain pre-exposure prophylaxis (PrEP) regimens to prevent HIV infection in individuals at high risk.
Side Effects[edit | edit source]
Common side effects include nausea, diarrhea, and headache. Serious side effects may include liver problems, kidney problems, and bone loss.
History[edit | edit source]
DTG/FTC/TAF was approved for medical use in the United States in 2019. It is marketed under the brand name Biktarvy by Gilead Sciences.
See Also[edit | edit source]
 | This pharmacology-related article is a stub. You can help WikiMD by expanding it. |
This HIV related article is a stub. You can help WikiMD by expanding it.
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
