Doublecortin like kinase 3

Ideogram human chromosome 3

Doublecortin like kinase 3

Doublecortin like kinase 3 (DCLK3) is a protein-coding gene that plays a crucial role in various cellular processes. It is a member of the doublecortin family of kinases and is involved in regulating cell proliferation, differentiation, and migration.

Function

DCLK3 is primarily expressed in the brain and is known to be involved in neuronal development and function. Studies have shown that DCLK3 plays a role in promoting the growth and survival of neurons, as well as regulating the formation of neuronal connections.

Structure

The DCLK3 gene encodes a protein that contains multiple functional domains, including a kinase domain that is responsible for its enzymatic activity. The protein structure of DCLK3 is highly conserved across species, indicating its importance in cellular processes.

Role in Disease

Mutations in the DCLK3 gene have been associated with certain neurological disorders, including epilepsy and neurodevelopmental disorders. Research is ongoing to further understand the role of DCLK3 in disease pathogenesis and potential therapeutic interventions.

Interactions

DCLK3 has been shown to interact with various proteins involved in signaling pathways that regulate cell growth and differentiation. These interactions play a critical role in coordinating cellular responses to external stimuli and maintaining cellular homeostasis.

Clinical Significance

Given its role in neuronal development and function, DCLK3 has emerged as a potential therapeutic target for neurological disorders. Targeting DCLK3 signaling pathways may offer new avenues for the treatment of conditions affecting the central nervous system.