EFNA2
EFNA2 is a gene that encodes the Ephrin-A2 protein in humans. Ephrin-A2 is a member of the Ephrin family, which plays a crucial role in the regulation of cell adhesion, growth, and migration.
Function[edit | edit source]
The EFNA2 gene is part of the Ephrin receptor signaling pathway, which is involved in a variety of biological processes. The protein encoded by this gene is a type-I membrane protein and is a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or maintenance of the nervous system.
Clinical Significance[edit | edit source]
Alterations in the EFNA2 gene have been associated with several types of cancer, including breast cancer and ovarian cancer. The overexpression of EFNA2 has been observed in these cancers, suggesting that it may play a role in tumor progression.
Interactions[edit | edit source]
EFNA2 has been shown to interact with EPHA2, a receptor that is part of the same signaling pathway. This interaction is important for the proper functioning of the pathway and the regulation of cell adhesion and migration.
See Also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
