EIF5AP1

Ideogram human chromosome 10

EIF5AP1

EIF5AP1 is a gene that encodes for the eukaryotic translation initiation factor 5A-1 (EIF5A-1). This protein is involved in the initiation of protein synthesis in eukaryotic cells. EIF5A-1 plays a crucial role in the translation of specific mRNAs that contain polyproline motifs.

Function

EIF5A-1 functions as a translation elongation factor and is essential for cell proliferation and survival. It is known to be involved in various cellular processes, including cell cycle progression, apoptosis, and stress response.

Structure

The EIF5A-1 protein consists of two domains: the N-terminal domain and the C-terminal domain. The N-terminal domain is responsible for the binding of EIF5A-1 to the ribosome, while the C-terminal domain interacts with mRNA and other translation factors.

Role in Disease

Mutations in the EIF5AP1 gene have been associated with certain diseases, including cancer. Dysregulation of EIF5A-1 expression has been linked to tumor growth and metastasis in various types of cancer.

Interactions

EIF5A-1 interacts with several other proteins involved in translation initiation and elongation, such as eIF5A-2 and eIF2. These interactions are crucial for the proper functioning of the translation machinery in cells.