EPH receptor B1
EPH receptor B1
EPH receptor B1 is a protein that in humans is encoded by the EPHB1 gene. It belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. This gene is a member of the Eph receptor family of receptor tyrosine kinases. The encoded protein is highly similar to the protein encoded by the EPHA1 gene.
Function[edit | edit source]
The protein encoded by this gene is a receptor for members of the ephrin-A family. It binds to ephrin-A1, -A3, -A4, and -A5. The ephrin receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
Clinical significance[edit | edit source]
Mutations in this gene have been associated with neurodevelopmental disorders, including autism spectrum disorders.
Interactions[edit | edit source]
EPH receptor B1 has been shown to interact with:
- EFNA1,
- EFNA3,
- EFNA4, and
- EFNA5.
See also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
