ERMAP

ERMAP (Erythroblast Membrane-Associated Protein) is a protein that in humans is encoded by the ERMAP gene. This protein is a cell surface transmembrane protein that is predominantly expressed in developing erythrocytes and endothelial cells. It has been implicated in the adhesion of erythroblasts to bone marrow stromal cells, a critical step in erythropoiesis, the process of producing red blood cells.

Function[edit | edit source]

ERMAP is a member of the SCAM family of proteins, which are characterized by the presence of a scavenger receptor cysteine-rich (SRCR) domain. The SRCR domain is a protein module that is found in a wide variety of proteins involved in the immune response. In the case of ERMAP, the SRCR domain is thought to mediate the protein's role in cell adhesion.

In addition to its role in erythropoiesis, ERMAP has also been implicated in the regulation of angiogenesis, the process of new blood vessel formation. This is due to its expression in endothelial cells, which line the interior surface of blood vessels and lymphatic vessels.

Clinical significance[edit | edit source]

Mutations in the ERMAP gene have been associated with blood disorders such as anemia and thalassemia. These disorders are characterized by a reduced ability to produce red blood cells, which can lead to symptoms such as fatigue, weakness, and shortness of breath.

Research[edit | edit source]

Research into ERMAP is ongoing, with scientists seeking to better understand its role in erythropoiesis and angiogenesis, as well as its potential as a therapeutic target for blood disorders.

File:ERMAP protein structure.jpg

The structure of the ERMAP protein. Image from Wikimedia Commons.