ERMAP
ERMAP (Erythroblast Membrane-Associated Protein) is a protein that in humans is encoded by the ERMAP gene. This protein is associated with the Scianna blood group system.
Function[edit | edit source]
ERMAP is a cell adhesion molecule that is expressed in erythroblasts and mature red blood cells. It plays a role in the adhesion of erythroid cells to the extracellular matrix and may be involved in the maturation of erythrocytes.
Clinical significance[edit | edit source]
Mutations in the ERMAP gene can lead to Scianna blood group system variations, which can be significant in blood transfusion and transplantation. The Scianna blood group system is one of the blood group systems recognized by the International Society of Blood Transfusion.
Structure[edit | edit source]
The ERMAP protein is a member of the immunoglobulin superfamily and contains immunoglobulin-like domains. It is a transmembrane protein with a single transmembrane helix.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
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Contributors: Prab R. Tumpati, MD
